Seok-ki Choi

About this team member

Dr. Choi is a research assistant professor at Michigan Nanotechnology Institute for Medicine and Biological Sciences (MNIMBS), Department of Internal Medicine, University of Michigan. He earned his BS and MS degrees both at Seoul National University, Korea, and PhD degree (1994) in Organic Chemistry at Columbia University, NY. His dissertation work under Professor Koji Nakanishi focused on synthesis of biologically active natural products and mode of action studies. He then joined in Professor George M. Whiteside laboratories at Harvard University as postdoctoral fellow where he performed proof of concept studies of polyvalent applications in biological systems focusing on pathogen-cell adhesion.

Dr. Choi started his career as research scientist at Theravance at South San Francisco in 1997, and played a significant role in exploring proprietary applications of polyvalent strategy for novel drug discovery. His research efforts led to discovery of several therapeutic candidates in clinical trials including those for treatment of asthma and chronic obstructive pulmonary diseases, and gastrointestinal motility, hetero-divalent antibacterial agents, and antihypertensive dual-acting small molecule inhibitors.

Dr. Choi joined in Michigan Nanotechnology Institute for Medicine and Biological Sciences in late 2008. His research interests focus on integration of polyvalent concept in biologic nanotechnology. His primary research objectives include rational design of nanodevices at molecular level for the cancer targeted delivery of therapeutic molecules. He is also investigating the problems of PAMAM dendrimer as the organophosphate agent-responsive drug carrier, and the design of photocleavable linkers for active drug release mechanisms in targeted delivery.

Publications

• Avidity Mechanism of Dendrimer-Folic Acid Conjugates MA van Dongen, JE Silpe, CA Dougherty, AK Kanduluru, SK Choi, BG, Orr, PS Low, MM Banaszak Holl Molecular Pharmaceutics 2014 11 1696-1706
• Dendrimer-Based Multivalent Vancomycin Nanoplatform for Targeting the Drug-Resistant Bacterial Surface S.K Choi, A. Myc, J.E. Silpe, M. Sumit, P.T. Wong, K. McCarthy, A.M. Desai, T.P. Thomas, A. Kotlyar, M. M. Banaszak Holl, B. G. Orr, J.R. Baker ACS Nano 2013 7 214-228
• Biophysical Characterization of a Riboflavin-Conjugated Dendrimer Platform for Targeted Drug Delivery A. B. Witte, C. M. Timmer, J. J. Gam, S. K. Choi, M. M. Banaszak Holl, B. G. Orr, J. R. Baker, K. Sinniah Biomacromolecules 2012 13 507-516
• Bioanalytical Screening of Riboflavin Antagonists for Targeted Drug Delivery-A Thermodynamic and Kinetic Study A. Plantinga, A Witte, M. H. Li, A. Harmon, S. K. Choi, M. M. Banaszak Holl, B. G. Orr, J. R. Baker, K. Sinniah ACS Medicinal Chemistry Letters 2011 2 363-367