Drug and Gene Delivery

Polyplex-Induced Cytosolic Nuclease Activation Leads to Differential Transgene Expression R. Rattan, S. Vaidyanathan, G. S.-H. Wu, A. Shakya, B. G. Orr, M. M. Banaszak Holl Molecular Pharmaceutics 2013 10 3013-3022
See: Rattan, Rahul Shakya, Anisha Vaidyanathan, Sriram
Epithelial-Mesenchymal Transition Enhances Nanoscale Actin Filament Dynamics of Ovarian Cancer Cells S. Lee, Y. Yang, D. Fishman, M. M. Banaszak Holl, S. Hong Journal of Physical Chemistry B 2013 117 9233-9240
PAMAM Dendrimers as Quantized Building Blocks for Novel Nanostructures M. A. van Dongen, S. Vaidyanathan, M. M. Banaszak Holl Soft Matter 2013 9 11188-11196
See: Vaidyanathan, Sriram van Dongen, Mallory
Avidity Modulation of Folated-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles J. E. Silpe, M. Sumit, T. P. Thomas, B. Huang, A. Kotlyar, M. A. van Dongen, M. M. Banaszak Holl, B. G. Orr, S. K. Choi ACS Chemical Biology 2013 8 2063-2071
See: Silpe, Justin van Dongen, Mallory
Bifunctional PAMAM Dendrimer Conjugates of Folic Acid and Methotrexate with Defined Ratio H. Zong K.-H. Lee, A. M. Desai, M.-H. Li, A. Kotlyar, Y. Zhang, P. R. Leroueil, J. J. Gam, M. M. Banaszak Holl, J. R. Baker Biomacromolecules 2012 13 982-991
See: Lee, Kyung-hoon
Dendrimer-Based Nanoparticle Therapies: Can Uniform Multifunctional Therapeutics Be Made with Current Chemical Approaches? D. G. Mullen, D. Q. McNerny, M. M. Banaszak Holl, J. R. Baker 2012
See: McNerny, Dan Mullen, Douglas
Cell Volume Changes During Apoptosis Monitored in Real Time Using Digital Holographic Microscopy A. Khmaladze, R. Matz, T. Epstein, J. Jasensky, M. M. Banaszak Holl, Z. Chen Journal of Structural Biology 2012 178 270-278
See: Matz, Becky
Dual-wavelength digital holographic imaging with phase background subtraction A. Khmaladze, R. Matz, J. Jasensky, E. Seeley, M. M. Banaszak Holl, Z. Chen Optical Engineering 2012 51 55801
See: Matz, Becky
Best Practices for Purification and Characterization of PAMAM Dendrimer D. G. Mullen, A. Desai, M. A. Van Dongen, M. Barash, J. R. Baker, M. M. Banaszak Holl Macromolecules 2012 45 5316-5320
See: Barash, Mark Mullen, Douglas van Dongen, Mallory
Efficient in vitro siRNA delivery and Intramuscular Gene Silencing using PEG-Modified PAMAM Dendrimers Y. Tang, Y.-B. Li, B. Wang, R.-Y. Lin, M. van Dongen, D. M. Zurcher, X.-Y. Gu, M. M. Banaszak Holl, G. Liu, R. Qi Molecular Pharmaceutics 2012 9 1812-1821
See: Rong Qi van Dongen, Mallory
Intrinsic Dynamics of DNA-Polymer Complexes: A Mechanism for DNA Release L. E. Prevette, E. N. Nikolova, H. M. Al-Hashimi, M. M. Banaszak Holl Molecular Pharmaceutics 2012 9 2743-2749
See: Prevette, Lisa
Dendrimer-based multivalent methotrexates as dual acting nanoconjugates for cancer cell targeting. M.H. Li, S. K. Choi, T. P. Thomas, A. Desai, K.-H. Lee, A. Kotlyar, M. M. Banaszak Holl, J. R. Baker European Journal of Medicinal Chemistry 2012 47 560-572
See: Lee, Kyung-hoon
Effect of pH and Generation on Structural Properties of Poly(amidoamine) Dendrons Studied by Molecular Dynamics Simulations K.-H. Lee, I. Lee, J. R. Baker, M. M. Banaszak Holl Journal of Computational and Theoretical Nanoscience 2012 9 122-126
See: Lee, Kyung-hoon
Biophysical Characterization of a Riboflavin-Conjugated Dendrimer Platform for Targeted Drug Delivery A. B. Witte, C. M. Timmer, J. J. Gam, S. K. Choi, M. M. Banaszak Holl, B. G. Orr, J. R. Baker, K. Sinniah Biomacromolecules 2012 13 507-516
See: Seok-ki Choi
Dual-wavelength linear regression phase unwrapping in three-dimensional microscopic images of cancer cells A. Khmaladze, R. L. Matz, C. Zhang, T. Wang, M. M. Banaszak Holl, Z. Chen. Optics Letters 2011 36 912-914
See: Matz, Becky
Acetonitrile Shortage: Use of isopropanol as an alternative elution system for ultrahigh performance liquid chromatograph A. M. Desai, M. Andreae, D. G. Mullen, M. M. Banaszak Holl, J. R. Baker Analytical Methods 2011 3 56-58.
See: Mullen, Douglas
Polyvalent saccharide-functionalized generation 3 poly(amidoamine) dendrimer-methotrexate conjugate as a potential anticancer agent. Y.-H. Zang, T. P. Thomas, K.-H. Lee, M. H. Li, H. Zong, A. M. Desai, A. Kotlyar, B. H. Hang, M. M. Banaszak Holl, J. R. Baker. Bioorganic & Medicinal Letters 2011 19 2557-2564
See: Lee, Kyung-hoon
Design, Synthesis, and Biological Functionality of a Dendrimer-based Modular Drug Delivery Platform . D. Mullen, D. McNerny, A. Desai, X.-M. Chen, S. DiMaggio, A. Kotlyar, Y. Zhong, S. Qin, C. V. Kelly, T. Thomas, I. Majoros, B. G. Orr, J. R. Baker, M. M. Banaszak Holl Bioconjugate Chemistry 2011 22 679-689
See: Stassi DiMaggio Kelly, Christopher McNerny, Dan Mullen, Douglas
Bioanalytical Screening of Riboflavin Antagonists for Targeted Drug Delivery-A Thermodynamic and Kinetic Study A. Plantinga, A Witte, M. H. Li, A. Harmon, S. K. Choi, M. M. Banaszak Holl, B. G. Orr, J. R. Baker, K. Sinniah ACS Medicinal Chemistry Letters 2011 2 363-367
See: Seok-ki Choi
Heterogeneous ligand-nanoparticle distributions: a major obstacle to scientific understanding and commercial translation D. G. Mullen, M. M. Banaszak Holl Accounts of Chemical Research 2011 44 1135-1252
See: Mullen, Douglas