Rattan, Rahul

About this team member

Rahul graduated from Panjab University, India in 2006 with a BE in Biotechnology. He is currently pursuing a PhD in Biomedical Engineering. He is characterizing the impact of dendrimer based drug delivery on mammalian cells, specifically the way these polymers and the polymer/DNA polyplexes interact with cell membranes and enter cells.

Rahul also has a substantial interest in translating ideas to the clinic and has also focused on invention. He was an active participant in the Ross Business School’s Dare to Dream program, the 2009 ASME Innovation Showcase (IShow) competition, and was recently a featured inventor at the University of Michigan’s annual Celebrate Inventation event. This event showcases inventors from all over campus and most typically highlights faculty led groups. Rahul’s invention, the Endocutter, was developed with a group of students originating from a project in a BME course. The Endocutter converts a traditional endoscope into a device that can cut up and remove blood clots, without damaging the stomach, making the identifical of bleeding areas in the stomach much more feasible and efficient. The invention can be viewed at http://www.youtube.com/watch?v=gxnB_kuzOsQ. This is wondeful example of biomedical innovation and points to Rahul’s powerful combination of strong science and engineering coupled with entrepreneurship.

Rahul is currently working at Celsee, Inc. a Bio-Rad company.

Awards

2008 Dare to Dream recipient (through University of Michigan Business School).

2008 BME Idea stipend award recipient (through NCIIA)

 

 

Publications

• Quantification of cytosolic plasmid DNA degradation using high-throughput sequencing: implications for gene delivery R. Rattan, A.U. Bielinska, M. M. Banaszak Holl Journal of Gene Medicine 2014 16 75-83
• Poly(amidoamine) Dendrimer-Methotrexate Conjugates: The Mechanism of Interaction with Folate Binding Protein M. A. van Dongen, R. Rattan, J. Silpe, C. Dougherty, N. L. Michmerhuizen, M. Van Winkle, B. Huang, S.-K. Choi, K. Sinniah, B.G. Orr, M. M. Banaszak Holl Molecular Pharmaceutics 2014 11 4049-4058
• Polyplex-Induced Cytosolic Nuclease Activation Leads to Differential Transgene Expression R. Rattan, S. Vaidyanathan, G. S.-H. Wu, A. Shakya, B. G. Orr, M. M. Banaszak Holl Molecular Pharmaceutics 2013 10 3013-3022
• The Role of Ganglioside GM1 in Cellular Internalization Mechanisms of Poly(amidoamine) Dendrimers S. Hong, R. Rattan, I. Majoros, D. G. Mullen, J. L. Peters, X. Shi, A. U. Bielinska, L. Blanco, B. G. Orr. J. R. Baker, M. M. Banaszak Holl Bioconjugate Chemistry 2009 20 1503-1513.